| Autor: |
Monica L. Reynolds, Keisha L. Gibson, Tracy A. Manuck, Caroline J. Poulton, Lauren Blazek, Alison M. Stuebe, Susan L. Hogan, Ronald J. Falk, Vimal K. Derebail |
| Jazyk: |
angličtina |
| Rok vydání: |
2024 |
| Předmět: |
|
| Zdroj: |
Frontiers in Nephrology, Vol 4 (2024) |
| Druh dokumentu: |
article |
| ISSN: |
2813-0626 |
| DOI: |
10.3389/fneph.2024.1402597 |
| Popis: |
Individuals with lupus nephritis (LN) are at high risk of adverse maternal and fetal outcomes in pregnancy. Outside of pregnancy, proliferative lesions on kidney biopsies are associated with disease progression, but these have not been consistently associated with increased risk in pregnancy. This retrospective, single-center study examines how histologic findings, the timing from kidney biopsy to pregnancy, and the clinical features in the first trimester are associated with preterm birth among individuals with LN. Among 35 deliveries in 31 women, the mean gestational age at delivery was 33.8 weeks. The presence of a urine protein-to-creatinine ratio >0.5 g/g in the first trimester was associated with preterm delivery (81% vs. 36%, p = 0.04). Preterm birth was more common in individuals with glomerular crescents on biopsy (89% in those with >20% crescents vs. 50% in those with |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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