EFFECT OF ALPHA TOCOPHEROL ON CHRONIC STRESS INDUCED DERANGEMENTS INN NEUROPEPTIDEY ON SPRAGUE DAWLEY RATS
| Autor: | Saadia Zainab, Umar Ali Khan, Ghulam Mustafa Lodhi, Munazza Asad |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: | |
| Zdroj: | Pakistan Armed Forces Medical Journal, Vol 70, Iss 3, Pp 776-780 (2020) |
| Druh dokumentu: | article |
| ISSN: | 0030-9648 2411-8842 |
| Popis: | Objective: To determine the chronic stress induced decline in plasma Neuropeptide Y (NPY) level and protective effects of Alpha Tocopherol (AT) on maintenance of Neuropeptide Y level. Study Design: Quasi-experimental study. Place and Duration of Study: The study settings were Al-Nafees Medical College and animal center of National Institute of Health Islamabad (NIH). Duration of research was one year from May 2015 to May 2016. Methodology: After taking approval of institutional review board 45 male Sprague Dawley rats with inclusion criteria were chosen and allocated to three groups comprised of n=15. Group I was control, group II restraint stress and group III (restraint stress with supplementation of alpha-tocopherol). After 28 days of restraining stress induction plasma Neuropeptide Y level was determined by sandwich Enzyme Linked Immunosorbent Assay (ELISA). Results: There was a statistically significant decline (p |
| Databáze: | Directory of Open Access Journals |
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