| Autor: |
Ngoc Buu Tran, Haesung Lee, Sook-Jeong Lee |
| Jazyk: |
angličtina |
| Rok vydání: |
2024 |
| Předmět: |
|
| Zdroj: |
Journal of Functional Foods, Vol 119, Iss , Pp 106333- (2024) |
| Druh dokumentu: |
article |
| ISSN: |
1756-4646 |
| DOI: |
10.1016/j.jff.2024.106333 |
| Popis: |
Insects are considered as a potentially eco-friendly, highly nutritious, and protein-rich food source. We evaluated the effects of Tenebrio molitor (Tm) and Protaetia brevitarsis seulensis (Pbs) extracts in a mouse model of D-galactose (D-Gal) aging, focusing on the impact of the insect extracts on neuronal viability, blood–brain barrier (BBB) integrity, and gut health. D-gal administration led to cognitive and behavioral deficits and increased anxiety levels. Tm and Pbs extracts increased glutathione, superoxide dismutase, and catalase levels; protected neurons in the brain, preventing BBB disruption and brain edema; and prevented the deposition of amyloid-β plaques in the prefrontal cortex and hippocampus. Furthermore, both extracts prevented disruption of gut epithelial integrity and mitigated intestinal inflammation. Our findings suggest a novel therapeutic potential of insect extracts against aging-related changes; they can be used as functional foods in the aging process by controlling the BBB and intestinal health. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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Full Text from ScienceDirect