Does cancer cell-expressed SLAMF7 impact on CD47-mediated phagocytosis?

Autor: Renee Bouwstra, Tom van Meerten, Edwin Bremer
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Zdroj: Molecular & Cellular Oncology, Vol 6, Iss 3 (2019)
Druh dokumentu: article
ISSN: 2372-3556
23723556
DOI: 10.1080/23723556.2019.1600349
Popis: Innate immune checkpoint CD47 has emerged as a prominent target for cancer immunotherapy and defining biomarkers predictive of response will be a crucial step towards clinical implementation. Hereto, we investigated the importance of a previously reported requisite for SLAM family member 7(SLAMF7) expression on cancer cell phagocytosis for effective CD47 antibody therapy.
Databáze: Directory of Open Access Journals
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