Microbiome differential abundance methods produce different results across 38 datasets

Autor: Jacob T. Nearing, Gavin M. Douglas, Molly G. Hayes, Jocelyn MacDonald, Dhwani K. Desai, Nicole Allward, Casey M. A. Jones, Robyn J. Wright, Akhilesh S. Dhanani, André M. Comeau, Morgan G. I. Langille
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
Druh dokumentu: article
ISSN: 2041-1723
DOI: 10.1038/s41467-022-28034-z
Popis: Many microbiome differential abundance methods are available, but it lacks systematic comparison among them. Here, the authors compare the performance of 14 differential abundance testing methods on 38 16S rRNA gene datasets with two sample groups, and show ALDEx2 and ANCOM-II produce the most consistent results.
Databáze: Directory of Open Access Journals