A renoprotective effect of enalapril in chronictransplantation nephropathy
| Autor: | N A Tomilina, A R Bagdasaryan, E S Stolyarevich, A V Sukhanov, N D Fedorova, I M Ilyinsky, V V Tyrin, A V Frolov |
|---|---|
| Jazyk: | ruština |
| Rok vydání: | 2004 |
| Předmět: | |
| Zdroj: | Терапевтический архив, Vol 79, Iss 9, Pp 47-52 (2004) |
| Druh dokumentu: | article |
| ISSN: | 0040-3660 2309-5342 |
| Popis: | Aim. To study safety and efficacy of ACE inhibitor enalapril in chronic transplantation nephropathy (CTN) as well as nephroprotective efficacy of this drug in various clinical variants of CTN. Material and methods. A retrospective study covered 220 recipients with CRF. The patients were divided into the study group (n = 103) and the control group (n = 117). The study group was given ACE inhibitor enalapril the efficacy of which was assessed by arterial pressure (systolic, diastolic, mean) dynamics, 24 h proteinuria and the rate of CTN progression. This rate was suggested by probability of plasm creatinin doubling (Kaplan-Meier technique). Results. Enalapril significantly inhibited CTN progression running with minimal or marked proteinuria, had a pronounced hypotensive effect, promoted stabilization of minimal proteinuria (in CTN with minimal proteinuria) or reduction of protein excretion (in a proteinuric variant of CTN). Conclusion. Use of enalapril in CTN in a daily dose 10 mg maximum is safe and can be used for inhibition of CTN progression. |
| Databáze: | Directory of Open Access Journals |
| Externí odkaz: |
|