| Autor: |
Jiayao Bai, Yinlin Ge, Changqi Zhao, Liu Yang, Keli Ge, Jinyu Zhang |
| Jazyk: |
angličtina |
| Rok vydání: |
2024 |
| Předmět: |
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| Zdroj: |
Journal of Functional Foods, Vol 118, Iss , Pp 106288- (2024) |
| Druh dokumentu: |
article |
| ISSN: |
1756-4646 |
| DOI: |
10.1016/j.jff.2024.106288 |
| Popis: |
Multiple metabolic diseases are caused by obesity. n-3 polyunsaturated fatty acids (n-3 PUFAs) could prevent obesity. However, the mechanism that n-3 PUFAs ameliorates energy metabolism disorder remains to be elucidated. This study attempted to investigate how n-3 PUFAs impact brown adipose tissue (BAT) and obesity-related signaling pathways in high-fat diet (HFD) induced obese mice. We used fat-1 transgenic mice as an animal model with high n-3 PUFAs. The results showed that n-3 PUFAs mitigated negative impacts of the HFD on the contents of glycaemic and lipid, diminished weight, white adipose tissue content and lipid hoarding in liver tissue, prevented BAT from being infiltrated, and increased microbiota diversity. N-3 PUFAs also upregulated serum interleukin-27 (IL-27) level and mRNAs, protein expression of the key BAT thermogenic genes, uncoupling protein-1 (UCP-1), uncoupling protein-2 (UCP-2). These results demonstrated that endogenous n-3 PUFAs increased BAT burning and energy consumption through the IL-27 pathway, inhibiting obesity. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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Full Text from ScienceDirect