| Autor: |
Stephanie Pei Yun Soh, Wei Yann See Toh, Wei Qing Ten, Khai Pang Leong, Liuh Ling Goh |
| Jazyk: |
angličtina |
| Rok vydání: |
2024 |
| Předmět: |
|
| Zdroj: |
Annals, Academy of Medicine, Singapore, Vol 53, Iss 3, Pp 208-210 (2024) |
| Druh dokumentu: |
article |
| ISSN: |
2972-4066 |
| DOI: |
10.47102/annals-acadmedsg.2023186 |
| Popis: |
Predicting optimal warfarin dosing is difficult due to complex pharmacodynamics and pharmacokinetics, narrow therapeutic index and susceptibility to many factors.1 Genetic variations of the CYP2C9 and VKORC1 enzymes, occurring in different frequencies in different populations, play a significant role in determining warfarin dosing.1-4 Using pharmacogenetic dosing algorithms to predict warfarin doses may shorten the time to achieve target International Normalised Ratio (INR) and stable dose.2,5 The Clinical Pharmacogenetics Implementation Consortium Guidelines 2017 Update4 recommends the Gage (WarfarinDosing.org7) and International Warfarin Pharmacogenetics Consortium (IWPC)8 pharmacogenetic algorithms. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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