| Autor: |
Ray Silva de Almeida, Jaime Ribeiro-Filho, Priscilla Ramos Freitas, Ana Carolina Justino de Araújo, Eduardo Lourenço dos Santos, Saulo Relison Tintino, Talysson Felismino Moura, Vitória Assunção Ferreira, Beatriz Assunção Ferreira, Victor Juno Alencar Fonseca, Pedro Ivo Palacio Leite, Ana Cristina Albuquerque da Silva, Luiz Everson da Silva, Wanderlei do Amaral, Cícero Deschamps, Abolghasem Siyadatpanah, Polrat Wilairatana, Henrique Douglas Melo Coutinho |
| Jazyk: |
angličtina |
| Rok vydání: |
2022 |
| Předmět: |
|
| Zdroj: |
Journal of Infection and Public Health, Vol 15, Iss 3, Pp 373-377 (2022) |
| Druh dokumentu: |
article |
| ISSN: |
1876-0341 |
| DOI: |
10.1016/j.jiph.2021.09.028 |
| Popis: |
In a recent study, our research group demonstrated that the essential oil of Ocotea odorifera (EOOO) and its major compound safrole potentiated the action fluoroquinolones, modulating bacterial resistance possibly due to direct inhibition of efflux pumps. Thus, in the present study, we investigated whether these treatments could enhance the activity of gentamicin and erythromycin against multidrug-resistant (MDR) bacteria. The EOOO was extracted by hydrodistillation, and the phytochemical analysis was performed by gas chromatography coupled to mass spectrometry (GC–MS). The antibiotic-enhancing effect of the EOOO and safrole against MDR strains of Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa was analyzed by the broth microdilution method. The chemical analysis confirmed the presence of safrole as a major component among the 16 compounds identified in the EOOO. Both the essential oil and the isolated compound showed clinically relevant antibacterial activities against S. aureus. Regarding the modulation of antibiotic resistance, the EOOO was found to enhance the activity of erythromycin against the strains of P. aeruginosa and S. aureus, as well as improving the action of gentamicin against S. aureus. On the other hand, safrole potentiated the activity of gentamicin against the S. aureus strain alone. It is concluded, therefore, that the EOOO and safrole can enhance the activity of macrolides and aminoglycosides, and as such are useful in the development of therapeutic tools to combat bacterial resistance against these classes of antibiotics. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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