Clinical implication in the use of the AAA algorithm versus the AXB in nasopharyngeal carcinomas by comparison of TCP and NTCP values

Autor:	Antonella Bufacchi, Orietta Caspiani, Giulia Rambaldi, Luca Marmiroli, Giuseppe Giovinazzo, Mattia Polsoni
Jazyk:	angličtina
Rok vydání:	2020
Předmět:	Dose volume histogram Tumor control probability Normal tissue complication probability Anisotropic analytical algorithm Acuros XB algorithm Medical physics. Medical radiology. Nuclear medicine R895-920 Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Zdroj:	Radiation Oncology, Vol 15, Iss 1, Pp 1-8 (2020)
Druh dokumentu:	article
ISSN:	1748-717X
DOI:	10.1186/s13014-020-01591-7
Popis:	Abstract Purpose Retrospective analysis of volumetric modulated arc therapy treatment plans to investigate qualitative, possible, clinical consequences of the use of AAA versus AXB in nasopharyngeal cancer (NPC) cases. Methods The dose distribution of 26 treatment plans, produced using RapidArc technique and AAA algorithm, were recalculated using AXB and the same number of monitor units provided by AAA and clinically delivered to each patient. The potential clinical effect of dosimetric differences in the planning target volume (PTV) and in organs at risk (OAR) were evaluated by comparing TCP and NTCP values. The Wilcoxon Signed Rank test was used for statistical comparison of all results obtained from the use of the two algorithms. Results The poorer coverage of the PTV, with higher prescribed dose, was reflected in the TCP, which was significantly lower when AXB was used, the median value was 81.55% (range: 74.90, 88.60%) and 84.10% (range: 77.70, 89.90%) for AAA (p
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/d108b8a1a0c248ff9e298924b62f0368 Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF Plný text ve formátu HTML
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