| Autor: |
Deyan Davidov |
| Jazyk: |
angličtina |
| Rok vydání: |
2008 |
| Předmět: |
|
| Zdroj: |
Journal of IMAB, Vol 14, Iss 1, Pp 51-54 (2008) |
| Druh dokumentu: |
article |
| ISSN: |
1312-773X |
| DOI: |
10.5272/jimab.14-1-2010.51 |
| Popis: |
Background: A platinum- based doublets with a third- generation agents /Gemcitabine, Vinorelbine/ represent the standard first- line treatment for advanced patients with non- small- cell lung cancer /NSCLC/ and good performance status. Aim: The aim of this study was to evaluate the two commonly used newer platinum- based regimes in response rate and survival. Methods: In the period 2005- 2007 ninety- four inoperable patients with NSCLC entered the study. The treatment schedule consist of Gemcitabine 1250 mg/m2 day 1 and 8 and cis- Platinum 80 mg/m2 with hydratation day 1- 46 patients /arm GP/ and Vinorelbine 30 mg/m2 day 1 and 8 and cis- Platinum 80 mg/m2 with hydratation day 1- 48 patients /arm VP/, every 21 days. Results: Overall response rate was 39% for GP and 32% for VP. Median survival was 10,3 and 9,8 months respectively. Neutropenia was significantly higher in arm VP as was thrombocytopenia on the GP arm. Conclusions: That data suggest that both regimes remain reasonable choices for patients with advanced NSCLC with slight prevalence of GP. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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