Association between Preoperative Plasma sRAGE Levels and Recovery from Cardiac Surgery
| Autor: | Benedict C. Creagh-Brown, Gregory J. Quinlan, Lauren R. Hector, Timothy W. Evans, Anne Burke-Gaffney |
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| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: | |
| Zdroj: | Mediators of Inflammation, Vol 2013 (2013) |
| Druh dokumentu: | article |
| ISSN: | 0962-9351 1466-1861 |
| DOI: | 10.1155/2013/496031 |
| Popis: | Background. The receptor for advanced glycation end products (RAGE) is an inflammation-perpetuating receptor, and soluble RAGE (sRAGE) is a marker of cellular RAGE expression. This study investigated whether raised plasma levels prior to surgery of sRAGE or S100A8/A9 (a RAGE ligand) were associated with longer duration of hospital care in patients undergoing cardiac surgery necessitating cardiopulmonary bypass. Methods. Patients (n=130) undergoing elective cardiac surgery were enrolled prospectively. Plasma sRAGE and S100A8/A9 concentrations were measured before and 2 h after surgery. Results. Preoperative plasma sRAGE increased significantly (P |
| Databáze: | Directory of Open Access Journals |
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