Ledderhose’s Disease: An Up-to-Date Review of a Rare Non-Malignant Disorder

Autor: Alexandru Tomac, Alexandru Petru Ion, Diana Roxana Opriș, Eliza Mihaela Arbănași, Claudiu Constantin Ciucanu, Bogdan Corneliu Bandici, Cătălin Mircea Coșarcă, Diana Carina Covalcic, Adrian Vasile Mureșan
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: Clinics and Practice, Vol 13, Iss 5, Pp 1182-1195 (2023)
Druh dokumentu: article
ISSN: 2039-7283
99312891
DOI: 10.3390/clinpract13050106
Popis: Plantar fibromatosis (or Ledderhose’s disease) is a rare benign condition, difficult to treat, defined by gradual-growing nodules in the central medial part of the plantar fascia, with the possibility of sclerosis and shrinkage of the entire fascia or, rarely, contractures of the toes. From a histopathological point of view, it is linked to Dupuytren’s contracture of the hand and Peyronie’s disease of the penis, being part of a large group of fibromatoses, based on a proliferation of collagen and fibroblasts. Its etiology is still not fully understood, even though it has been associated with trauma, diabetes mellitus, use of anticonvulsants, frozen shoulder, alcohol consumption, and liver disease. Typically, ultrasound confirms the diagnosis, and magnetic resonance imaging is used for more aggressive and advanced types. Several conservative treatment techniques, such as steroid injections, verapamil, imatinib, radiation therapy, extracorporeal shock wave therapy, tamoxifen, sorafenib, mitomycin C, and collagenase, have been documented. When non-operative care fails, surgical measures may be considered, even though recurrence is expected. We attempted to provide a better understanding of this disease by covering all of the important aspects: its history, clinical and radiologic findings, diagnosis, pathophysiology features, conservative and surgical treatment, recurrence rate, and prognosis.
Databáze: Directory of Open Access Journals
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