Determining Reference Ranges for Total T4 in Dried Blood Samples for Newborn Screening

Autor: Anna-Isabella Hijman, Daniel Konrad, Ralph Fingerhut
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Zdroj: International Journal of Neonatal Screening, Vol 6, Iss 1, p 17 (2020)
Druh dokumentu: article
ISSN: 2409-515X
DOI: 10.3390/ijns6010017
Popis: The purpose of this study was to define reference intervals for total thyroxine (tT4) in dried blood samples (DBSs) obtained for newborn screening. The aim of our study was to assess the possible benefit of measuring tT4 concentrations directly in DBSs obtained for newborn screening in premature and term-born infants. In order to have a sufficient number of samples for the extremely premature infants (4 stability in DBSs. We found that tT4 strongly correlated with gestational age (GA) in premature infants, highlighting the need for age-specific reference ranges. For term-born infants, the tT4 ranges did not vary significantly among different gestational ages, allowing for the use of one single reference range.
Databáze: Directory of Open Access Journals