Nanostructures as Targeted Therapeutics for Combating Oral Bacterial Diseases

Autor: Shima Afrasiabi, Nasim Chiniforush, Hamid Reza Barikani, Alireza Partoazar, Ramin Goudarzi
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: Biomedicines, Vol 9, Iss 10, p 1435 (2021)
Druh dokumentu: article
ISSN: 2227-9059
DOI: 10.3390/biomedicines9101435
Popis: Pathogenic oral biofilms are now recognized as a key virulence factor in many microorganisms that cause the heavy burden of oral infectious diseases. Recently, new investigations in the nanotechnology field have propelled the development of novel biomaterials and approaches to control bacterial biofilms, either independently or in combination with other substances such as drugs, bioactive molecules, and photosensitizers used in antimicrobial photodynamic therapy (aPDT) to target different cells. Moreover, nanoparticles (NPs) showed some interesting capacity to reverse microbial dysbiosis, which is a major problem in oral biofilm formation. This review provides a perspective on oral bacterial biofilms targeted with NP-mediated treatment approaches. The first section aims to investigate the effect of NPs targeting oral bacterial biofilms. The second part of this review focuses on the application of NPs in aPDT and drug delivery systems.
Databáze: Directory of Open Access Journals