| Autor: |
Maximilian Buegler, Robbert L. Harms, Mircea Balasa, Irene B. Meier, Themis Exarchos, Laura Rai, Rory Boyle, Adria Tort, Maha Kozori, Eutuxia Lazarou, Michaela Rampini, Carlo Cavaliere, Panagiotis Vlamos, Magda Tsolaki, Claudio Babiloni, Andrea Soricelli, Giovanni Frisoni, Raquel Sanchez‐Valle, Robert Whelan, Emilio Merlo‐Pich, Ioannis Tarnanas |
| Jazyk: |
angličtina |
| Rok vydání: |
2020 |
| Předmět: |
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| Zdroj: |
Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, Vol 12, Iss 1, Pp n/a-n/a (2020) |
| Druh dokumentu: |
article |
| ISSN: |
2352-8729 |
| DOI: |
10.1002/dad2.12073 |
| Popis: |
Abstract Background Research investigating treatments and interventions for cognitive decline fail due to difficulties in accurately recognizing behavioral signatures in the presymptomatic stages of the disease. For this validation study, we took our previously constructed digital biomarker‐based prognostic models and focused on generalizability and robustness of the models. Method We validated prognostic models characterizing subjects using digital biomarkers in a longitudinal, multi‐site, 40‐month prospective study collecting data in memory clinics, general practitioner offices, and home environments. Results Our models were able to accurately discriminate between healthy subjects and individuals at risk to progress to dementia within 3 years. The model was also able to differentiate between people with or without amyloid neuropathology and classify fast and slow cognitive decliners with a very good diagnostic performance. Conclusion Digital biomarker prognostic models can be a useful tool to assist large‐scale population screening for the early detection of cognitive impairment and patient monitoring over time. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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