| Autor: |
Yunhao Cui, Taisia Rolova, Susanna C. Fagerholm |
| Jazyk: |
angličtina |
| Rok vydání: |
2024 |
| Předmět: |
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| Zdroj: |
European Journal of Cell Biology, Vol 103, Iss 3, Pp 151441- (2024) |
| Druh dokumentu: |
article |
| ISSN: |
0171-9335 |
| DOI: |
10.1016/j.ejcb.2024.151441 |
| Popis: |
Integrins are heterodimeric membrane proteins expressed on the surface of most cells. They mediate adhesion and signaling processes relevant for a wealth of physiological processes, including nervous system development and function. Interestingly, integrins are also recognized therapeutic targets for inflammatory diseases, such as multiple sclerosis. Here, we discuss the role of integrins in brain development and function, as well as in neurodegenerative diseases affecting the brain (Alzheimer’s disease, multiple sclerosis, stroke). Furthermore, we discuss therapeutic targeting of these adhesion receptors in inflammatory diseases of the brain. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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Full Text from ScienceDirect