GENETIC BIOMARKERS OF GLIAL BRAIN TUMORS: IDH1 AND IDH2 MUTATIONS
| Autor: | M. Yu. Prokudin, B. V. Martynov, D. V. Svistov, I. V. Litvinenko, E. N. Imyanitov, V. S. Chirsky, S. E. Bushurov, A. I. Yakovenko, K. A. Chemodakova, O. A. Klitsenko, O. A. Gorustovich, G. F. Medvedeva, A. R. Bulatov |
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| Jazyk: | ruština |
| Rok vydání: | 2020 |
| Předmět: | |
| Zdroj: | Сибирский онкологический журнал, Vol 19, Iss 4, Pp 59-66 (2020) |
| Druh dokumentu: | article |
| ISSN: | 1814-4861 2312-3168 |
| DOI: | 10.21294/1814-4861-2020-19-4-59-66 |
| Popis: | Introduction. Mutations in the isocytrate dehydrogenase 1 and 2 genes (IDH1 and IDH2) are considered driver genetic events in gliomas. Their frequency reaches 7080 % in low-grade gliomas and in secondary glioblastomas, and their oncogenic effect is realized by accumulation of the metabolite 2-hydroxyglutarate, which disrupts DNA and protein methylation processes. The aim of the study was to analyze the associations between the presence of IDH1/2 mutations and clinical and morphological parameters of glial tumors. Material and Methods. The study included 147 patients with glial brain tumors. Associations between IDH1/2 status and tumor histological type, age of disease onset, tumor localization, and clinical manifestations were investigated. Results. Gliomas containing IDH1/2 mutations were characterized by a younger age at diagnosis (mean: 39.5 years) compared to IDH-negative cases (47.2 years) (p |
| Databáze: | Directory of Open Access Journals |
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