Implications of asymptomatic malaria infections on hematologic parameters in adults living with HIV in malaria-endemic regions with varying transmission intensities

Autor: Edwin Kamau, Risper Maisiba, Nicole Dear, Allahna Esber, Ajay P. Parikh, Michael Iroezindu, Emmanuel Bahemana, Hannah Kibuuka, John Owuoth, Jonah Maswai, Benjamin Opot, Raphael O. Okoth, Farid Abdi, Maureen Mwalo, Dennis Juma, Ben Andagalu, Hoseah M. Akala, Neha Shah, Trevor A. Crowell, Jessica Cowden, Christina S. Polyak, Julie A. Ake
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: International Journal of Infectious Diseases, Vol 137, Iss , Pp 82-89 (2023)
Druh dokumentu: article
ISSN: 1201-9712
DOI: 10.1016/j.ijid.2023.09.018
Popis: Objectives: HIV and malaria coinfection impacts disease management and clinical outcomes. This study investigated hematologic abnormalities in malaria-asymptomatic people living with HIV (PLHIV) in regions with differing malaria transmission. Methods: Study participants were enrolled in the African Cohort Study: two sites in Kenya, one in Uganda, and one in Nigeria. Data was collected at enrollment and every 6 months. Logistic regression estimated odds ratios for associations between HIV/malaria status and anemia, thrombocytopenia, and leucopenia. Results: Samples from 1587 participants with one or more visits comprising 1471 (92.7%) from PLHIV and 116 (7.3%) without HIV were analyzed. Parasite point prevalence significantly differed across the study sites (P
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