Improved pentamethine cyanine nanosensors for optoacoustic imaging of pancreatic cancer

Autor: Matthew D. Laramie, Benjamin L. Fouts, William M. MacCuaig, Emmanuel Buabeng, Meredith A. Jones, Priyabrata Mukherjee, Bahareh Behkam, Lacey R. McNally, Maged Henary
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Druh dokumentu: article
ISSN: 2045-2322
DOI: 10.1038/s41598-021-83658-3
Popis: Abstract Optoacoustic imaging is a new biomedical imaging technology with clear benefits over traditional optical imaging and ultrasound. While the imaging technology has improved since its initial development, the creation of dedicated contrast agents for optoacoustic imaging has been stagnant. Current exploration of contrast agents has been limited to standard commercial dyes that have already been established in optical imaging applications. While some of these compounds have demonstrated utility in optoacoustic imaging, they are far from optimal and there is a need for contrast agents with tailored optoacoustic properties. The synthesis, encapsulation within tumor targeting silica nanoparticles and applications in in vivo tumor imaging of optoacoustic contrast agents are reported.
Databáze: Directory of Open Access Journals
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