| Autor: |
Bashir Daoud Agha Dit Daoudy, Mohammad Ammar Al-Khayat, Ghassan Abo Chameh, Mohammad Amer Al Mardini |
| Jazyk: |
angličtina |
| Rok vydání: |
2024 |
| Předmět: |
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| Zdroj: |
Advances in Pharmacological and Pharmaceutical Sciences, Vol 2024 (2024) |
| Druh dokumentu: |
article |
| ISSN: |
2633-4690 |
| DOI: |
10.1155/adpp/4971456 |
| Popis: |
This study demonstrated the impact of formic acid (FAc), a common reactive impurity in pharmaceutical excipients, on the stability of mirabegron (MB). The investigation of MB-excipient compatibility tests revealed the formation of a new degradation product, FAc-DP, at 0.2% after 7 days of isothermal stress at 55°C. FAc-DP was synthesized and characterized as N-formyl MB using liquid chromatography–mass spectrometry (LC-MS) and both 1D and 2D nuclear magnetic resonance spectroscopy (NMR). |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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