Single‐nucleotide polymorphism at alcohol dehydrogenase 1B: A susceptible gene marker in oro‐/hypopharyngeal cancers from genome‐wide association study

Autor:	Hui‐Tzu Chien, Chia‐Lung Tsai, Chi‐Kuan Young, Yun‐Shien Lee, Chun‐Ta Liao, Chih‐Ching Yeh, Angel Chao, Kai‐Lun Cho, Ching‐Han Chen, Shiang‐Fu Huang
Jazyk:	angličtina
Rok vydání:	2023
Předmět:	alcohol dehydrogenase 1B aldehyde dehydrogenase 2 genome‐wide association study head and neck cancer oropharyngeal cancer Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Zdroj:	Cancer Medicine, Vol 12, Iss 18, Pp 19174-19187 (2023)
Druh dokumentu:	article
ISSN:	2045-7634
DOI:	10.1002/cam4.6506
Popis:	Abstract Introduction In the era of precision preventive medicine, susceptible genetic markers for oro‐/hypopharyngeal squamous cell carcinoma (OPSCC) have been investigated for genome‐wide associations. Materials and Methods A case–control study including 659 male head and neck squamous cell carcinoma (HNSCC) patients, including 331 oropharyngeal cancer, treated between March 1996 and December 2016 and 2400 normal controls was performed. A single‐nucleotide polymorphism (SNP) array was used to determine genetic loci that increase susceptibility to OPSCC. Results We analyzed the allele frequencies of 664,994 autosomal SNPs in 659 HNSCC cases; 7 SNPs scattered in loci of chromosomes 5, 7, 9, 11, and 19 were significant in genome‐wide association analysis (Pc
Databáze:	Directory of Open Access Journals
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