| Autor: |
Bjørn A Nexø, Tove Christensen, Jette Frederiksen, Anné Møller-Larsen, Annette B Oturai, Palle Villesen, Bettina Hansen, Kari K Nissen, Magdalena J Laska, Trine S Petersen, Sandra Bonnesen, Anne Hedemand, Tingting Wu, Xinjie Wang, Xiuqing Zhang, Tomasz Brudek, Romana Maric, Helle B Søndergaard, Finn Sellebjerg, Klaus Brusgaard, Anders L Kjeldbjerg, Henrik B Rasmussen, Anders L Nielsen, Mette Nyegaard, Thor Petersen, Anders D Børglum, Finn S Pedersen |
| Jazyk: |
angličtina |
| Rok vydání: |
2011 |
| Předmět: |
|
| Zdroj: |
PLoS ONE, Vol 6, Iss 2, p e16652 (2011) |
| Druh dokumentu: |
article |
| ISSN: |
1932-6203 |
| DOI: |
10.1371/journal.pone.0016652 |
| Popis: |
We have investigated the role of human endogenous retroviruses in multiple sclerosis by analyzing the DNA of patients and controls in 4 cohorts for associations between multiple sclerosis and polymorphisms near viral restriction genes or near endogenous retroviral loci with one or more intact or almost-intact genes. We found that SNPs in the gene TRIM5 were inversely correlated with disease. Conversely, SNPs around one retroviral locus, HERV-Fc1, showed a highly significant association with disease. The latter association was limited to a narrow region that contains no other known genes. We conclude that HERV-Fc1 and TRIM5 play a role in the etiology of multiple sclerosis. If these results are confirmed, they point to new modes of treatment for multiple sclerosis. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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