| Autor: |
Jae-Hwan Chung, Sang-Jun Lee, Jin-Oh Chung, Yu-Jin Oh, Jeong-Ah Hwang, Young-Kyung Kim, Sanghoon Ko, Soon-Mi Shim |
| Jazyk: |
angličtina |
| Rok vydání: |
2014 |
| Předmět: |
|
| Zdroj: |
Integrative Medicine Research, Vol 3, Iss 1, Pp 34-37 (2014) |
| Druh dokumentu: |
article |
| ISSN: |
2213-4220 |
| DOI: |
10.1016/j.imr.2013.11.001 |
| Popis: |
Background: The purpose of this study was to investigate the effect of hydroxypropyl methyl cellulose phthalate (HPMCP) coating on the digestive stability and intestinal transport of green tea catechins (GTCs). Methods: Two types of HPMCP coating were prepared: one type with size smaller than 500 μm (S-HPMCP) and the other with size larger than 500 μm (L-HPMCP). An in vitro gastrointestinal model system coupled with Caco-2 cells was used for estimating the bioavailability of GTCs. Ultraperformance liquid chromatography with a photodiode array detector was performed to analyze GTCs. Results: The digestive stability of GTCs was enhanced up to 33.73% and 35.28% for S-HPMCP and L-HPMCP, respectively. Intestinal transport of the GTCs was increased to 22.98% and 23.23% for S-HPMCP and L-HPMCP, respectively. Overall, the bioavailability of GTCs increased by 4.08 and 11.71 times for S-HPMCP and L-HPMCP, respectively. Conclusion: The results of this study confirm that coating with HPMCP could be a way to improve the digestive stability and intestinal transport of GTCs. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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