Extraction of Hydroxyapatite Nanostructures from Marine Wastes for the Fabrication of Biopolymer-Based Porous Scaffolds

Autor: Hengameh Gheysari, Fatemeh Mohandes, Mozhdeh Mazaheri, Banafsheh Dolatyar, Masoud Askari, Abdolreza Simchi
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Zdroj: Marine Drugs, Vol 18, Iss 1, p 26 (2019)
Druh dokumentu: article
ISSN: 1660-3397
DOI: 10.3390/md18010026
Popis: Three-dimensional porous nanocomposites consisting of gelatin-carboxymethylcellulose (CMC) cross-linked by carboxylic acids biopolymers and monophasic hydroxyapatite (HA) nanostructures were fabricated by lyophilization, for soft-bone-tissue engineering. The bioactive ceramic nanostructures were prepared by a novel wet-chemical and low-temperature procedure from marine wastes containing calcium carbonates. The effect of surface-active molecules, including sodium dodecyl sulfate (SDS) and hexadecyltrimethylammonium bromide (CTAB), on the morphology of HA nanostructures is shown. It is demonstrated that highly bioactive and monophasic HA nanorods with an aspect ratio > 10 can be synthesized in the presence of SDS. In vitro studies on the bioactive biopolymer composite scaffolds with varying pore sizes, from 100 to 300 μm, determine the capacity of the developed procedure to convert marine wastes to profitable composites for tissue engineering.
Databáze: Directory of Open Access Journals