Cryo-EM structure of type 1 IP3R channel in a lipid bilayer

Autor: Mariah R. Baker, Guizhen Fan, Alexander B. Seryshev, Melina A. Agosto, Matthew L. Baker, Irina I. Serysheva
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: Communications Biology, Vol 4, Iss 1, Pp 1-11 (2021)
Druh dokumentu: article
ISSN: 2399-3642
DOI: 10.1038/s42003-021-02156-4
Popis: 3D structure of full-length rat type 1 inositol 1,4,5-trisphosphate receptor reconstituted in lipid nanodisc is determined using single-particle cryo-electron microscopy. The study suggests conserved locations of protein-bound lipids among structurally diverse, homo-tetrameric ion channels.
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