| Autor: |
Tyler Myers, Amina Bouslimani, Shi Huang, Shalisa T. Hansen, Cécile Clavaud, Anissa Azouaoui, Alban Ott, Audrey Gueniche, Charbel Bouez, Qian Zheng, Luc Aguilar, Rob Knight, Magali Moreau, Se Jin Song |
| Jazyk: |
angličtina |
| Rok vydání: |
2024 |
| Předmět: |
|
| Zdroj: |
Frontiers in Aging, Vol 4 (2024) |
| Druh dokumentu: |
article |
| ISSN: |
2673-6217 |
| DOI: |
10.3389/fragi.2023.1304705 |
| Popis: |
Introduction: During adulthood, the skin microbiota can be relatively stable if environmental conditions are also stable, yet physiological changes of the skin with age may affect the skin microbiome and its function. The microbiome is an important factor to consider in aging since it constitutes most of the genes that are expressed on the human body. However, severity of specific aging signs (one of the parameters used to measure “apparent” age) and skin surface quality (e.g., texture, hydration, pH, sebum, etc.) may not be indicative of chronological age. For example, older individuals can have young looking skin (young apparent age) and young individuals can be of older apparent age.Methods: Here we aim to identify microbial taxa of interest associated to skin quality/aging signs using a multi-study analysis of 13 microbiome datasets consisting of 16S rRNA amplicon sequence data and paired skin clinical data from the face.Results: We show that there is a negative relationship between microbiome diversity and transepidermal water loss, and a positive association between microbiome diversity and age. Aligned with a tight link between age and wrinkles, we report a global positive association between microbiome diversity and Crow’s feet wrinkles, but with this relationship varying significantly by sub-study. Finally, we identify taxa potentially associated with wrinkles, TEWL and corneometer measures.Discussion: These findings represent a key step towards understanding the implication of the skin microbiota in skin aging signs. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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