Pro‐ and anti‐inflammatory cytokines mediate the progression of severe anemia in malaria‐infected children: A prospective study

Autor: Charles Nkansah, Felix Osei‐Boakye, Gabriel Abbam, Samuel K. Appiah, Samira Daud, Bright Boakye, Samsiyatu Abdulai, Madina Ahmed, Theophilus B. Antwi, Birago Boateng, Miigbat P. Libatin, Alexander S. Mensah, Mary K. Missah, Richard V. Duneeh, Ashiya Haruna, Stephany Adda, Pagnaa G. Abdul‐Rauf, Zacharia A. Ofori, George B. Fosu, Sandra Segnitome, Isaac Adjei, Emmanuel Appiah‐Kubi, Moses Banyeh, Charles A. Derigubah, Muniru M. Tanko, Ejike F. Chukwurah
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: Immunity, Inflammation and Disease, Vol 12, Iss 9, Pp n/a-n/a (2024)
Druh dokumentu: article
ISSN: 2050-4527
DOI: 10.1002/iid3.70013
Popis: Abstract Background Severe Plasmodium falciparum malarial anemia is still the principal cause of death in children in underdeveloped countries. An imbalance between proinflammatory and anti‐inflammatory cytokines is associated with malaria progression. This study evaluated circulating levels of selected inflammatory cytokines among malaria‐infected children in Ghana. Methods This case‐control study was conducted at Tamale Teaching Hospital, Ghana. One hundred and twenty children with malaria and 60 controls, aged 12−144 months were selected from April to July, 2023 for the study. Malaria was diagnosed through microscopy, full blood count was measured using hematology analyzer, and cytokines were measured using enzyme‐linked immunosorbent assay. Results Malaria‐infected children had higher tumor necrosis factor alpha (TNF‐α) (p
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