Relationship between circulating interleukin-10 and histological features in patients with chronic C hepatitis
| Autor: | Bruno Cosimo, Valenti Maria, Bertino Gaetano, Ardiri Annalisa, Amoroso Alfredo, Consolo Maria, Mazzarino Clorinda, Neri Sergio |
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| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: | |
| Zdroj: | Annals of Saudi Medicine, Vol 31, Iss 4, Pp 360-364 (2011) |
| Druh dokumentu: | article |
| ISSN: | 0256-4947 0975-4466 |
| Popis: | Background and Objectives: An imbalance in cytokine production may be involved in the pathogenesis of chronic C hepatitis. The aim of the study was to investigate circulating levels of interleukin-10 (IL-10) in a selected cohort of patients affected by chronic C hepatitis. Design and Setting: Retrospective study based on consecutive hepatitis C virus patients, affected by chronic active hepatitis, attending the general hospital of hepatology unit from June to September 2009 Patients and Methods: A total of 49 patients with chronic C hepatitis and 20 healthy control subjects similar in gender and age were examined. Circulating IL-10 was assessed by ELISA commercial kit (R and D Systems) in all investigated subjects. Results: There was no significant difference in IL-10 values between controls and overall patients (P>.05). Nevertheless, among patients, subjects with more severe necroinflammation had higher values than others (PPConclusions: These findings suggest that IL-10 may be a useful additional marker to assess necroinflammation and to monitor the evolution of liver damage. They also argue for a potential pathophysiological role for IL-10 in the persistence and progression of hepatitis. |
| Databáze: | Directory of Open Access Journals |
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