Overview of the Maturation Machinery of the H-Cluster of [FeFe]-Hydrogenases with a Focus on HydF

Autor:	Marco Bortolus, Paola Costantini, Davide Doni, Donatella Carbonera
Jazyk:	angličtina
Rok vydání:	2018
Předmět:	hydrogenases [FeFe]-hydrogenases HydF HydG HydE maturases Biology (General) QH301-705.5 Chemistry QD1-999
Zdroj:	International Journal of Molecular Sciences, Vol 19, Iss 10, p 3118 (2018)
Druh dokumentu:	article
ISSN:	1422-0067
DOI:	10.3390/ijms19103118
Popis:	Hydrogen production in nature is performed by hydrogenases. Among them, [FeFe]-hydrogenases have a peculiar active site, named H-cluster, that is made of two parts, synthesized in different pathways. The cubane sub-cluster requires the normal iron-sulfur cluster maturation machinery. The [2Fe] sub-cluster instead requires a dedicated set of maturase proteins, HydE, HydF, and HydG that work to assemble the cluster and deliver it to the apo-hydrogenase. In particular, the delivery is performed by HydF. In this review, we will perform an overview of the latest knowledge on the maturation machinery of the H-cluster, focusing in particular on HydF.
Databáze:	Directory of Open Access Journals
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