| Autor: |
Fausto Zaruma-Torres, Ismael Lares-Asseff, Verónica Loera-Castañeda, Aurea Lima, Aarón Reyes-Espinoza, Martha Sosa-Macías, Carlos Galaviz-Hernández, María Cristina Arias-Pelaez, Miguel Angel Reyes-López, Luis Abel Quiñones |
| Jazyk: |
angličtina |
| Rok vydání: |
2016 |
| Předmět: |
|
| Zdroj: |
Frontiers in Pharmacology, Vol 7 (2016) |
| Druh dokumentu: |
article |
| ISSN: |
1663-9812 |
| DOI: |
10.3389/fphar.2016.00238 |
| Popis: |
Acute lymphoblastic leukemia (ALL) is a frequent neoplasia occurring in children. The most commonly used drug for the treatment of ALL is methotrexate (MTX), an anti-folate agent. Previous studies suggest that folate transporters play a role in ALL prognosis and that genetic polymorphism of genes encoding folate transporters may increase the risk of ALL. Therefore, the main goal of this study was to determine the associations among six genetic polymorphisms in four genes related with the folate transporter pathway to determine a relationship with the occurrence of ALL in Mexican children.A case-control study was performed in 73 ALL children and 133 healthy children from Northern and Northwestern Mexico. COL18A1 (rs2274808), SLC19A1 (rs2838956), ABCB1 (rs1045642 and rs1128503) and ABCC5 (rs9838667 and rs3792585). polymorphisms were assayed through qPCR.Our results showed an increased ALL risk in children carrying CT genotype (OR=2.55, CI 95% 1.11-5.83, p=0.0001) and TT genotype (OR=21.05, CI 95% 5.62-78.87, p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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