| Autor: |
Chioma Ifeoma Ibe, Eze Elijah Ajaegbu, Amara Anwuchaepe Ajaghaku, Peter Maduabuchi Eze, Ifeanyi Peter Onyeka, Christopher Obidike Ezugwu, Festus Basden Chiedu Okoye |
| Jazyk: |
angličtina |
| Rok vydání: |
2022 |
| Předmět: |
|
| Zdroj: |
Phytomedicine Plus, Vol 2, Iss 4, Pp 100335- (2022) |
| Druh dokumentu: |
article |
| ISSN: |
2667-0313 |
| DOI: |
10.1016/j.phyplu.2022.100335 |
| Popis: |
Background: In Africa, Piliostigma thonningii is utilized traditionally for the treatment of dysentery, diarrhea, and various stomach complications. Purpose: The study's aim is the screening of the extract/fractions of P. thonningii for antioxidant activities and isolation of some of the components. Methods: The root bark was extracted with methanol and subjected to further purification using liquid-liquid partitioning and chromatographic techniques. The isolated compounds were characterized by utilizing HPLC-DAD and 1D NMR spectroscopy. Results: The ethyl acetate fraction displayed best activity with total phenol content of 270 mgGAE/g, IC50 of 60.24 µg/ml (2,2-diphenyl-1-picrylhydrazyl (DPPH) assay) and EC50 of 653.4 µg/ml (ferric-reducing antioxidant power (FRAP) assay). For the in vivo antioxidant assay at 200 and 400 mg/kg, the ethyl acetate fraction produced significant (p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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