| Autor: |
Gen Inoue, Takashi Kaito, Yukihiro Matsuyama, Toshihiko Yamashita, Mamoru Kawakami, Kazuhisa Takahashi, Munehito Yoshida, Shiro Imagama, Seiji Ohtori, Toshihiko Taguchi, Hirotaka Haro, Hiroshi Taneichi, Masashi Yamazaki, Kotaro Nishida, Hiroshi Yamada, Daijiro Kabata, Ayumi Shintani, Motoki Iwasaki, Manabu Ito, Naohisa Miyakoshi, Hideki Murakami, Kazuo Yonenobu, Tomoyuki Takura, Joji Mochida |
| Jazyk: |
angličtina |
| Rok vydání: |
2021 |
| Předmět: |
|
| Zdroj: |
Spine Surgery and Related Research, Vol 5, Iss 4, Pp 252-263 (2021) |
| Druh dokumentu: |
article |
| ISSN: |
2432-261X |
| DOI: |
10.22603/ssrr.2020-0083 |
| Popis: |
Introduction: Chronic low back pain (CLBP) is a leading cause of disability, yet there is limited high-quality evidence to identify the most suitable pharmacological therapy. The purpose of this Japanese nationwide, multicenter, prospective study was to compare the effectiveness of four representative drug therapies―acetaminophen, celecoxib, loxoprofen, and a tramadol and acetaminophen (T+A) combination drug―to establish evidence for a drug of choice for CLBP. Methods: Patients with CLBP (N=471) received one of the four treatments and were evaluated, prospectively and comprehensively, once every month for six months using a visual analog scale (VAS) for LBP, the Japanese Orthopedic Association (JOA) score, the JOA Back Pain Evaluation Questionnaire (JOABPEQ), the Roland-Morris Disability Questionnaire (RDQ), the EuroQol five-dimensions three-levels (EQ-5D-3L), and the Short Form-8 item health survey (SF-8). We conducted multivariable linear regression analyses of the four drugs at 1 and 6 months after drug allocation. Differences with P |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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