Lesões em DNA induzidas pela autoxidação de S(IV) na presença de íons metálicos de transição
| Autor: | Ruben G. M. Moreno, María V. Alipázaga, Marisa H. G. Medeiros, Nina Coichev |
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| Jazyk: | English<br />Spanish; Castilian<br />Portuguese |
| Rok vydání: | 2006 |
| Předmět: | |
| Zdroj: | Química Nova, Vol 29, Iss 5, Pp 1086-1093 (2006) |
| Druh dokumentu: | article |
| ISSN: | 1678-7064 0100-4042 |
| DOI: | 10.1590/S0100-40422006000500032 |
| Popis: | The oxidation of sulfite catalyzed by transition metal ions produces reactive oxysulfur species that can damage plasmid and isolated DNA in vitro. Among the four DNA bases, guanine is the most sensitive to one-electron oxidation promoted by the species formed in the autoxidation of sulfite (HSO5-, HO•, SO3•-, SO4•- and SO5•-) due to its low reduction potential and ability to bind transition metal ions capable to catalyze oxidative processes. Some oxidative DNA lesions are promutagenic and oxidative DNA damage is proposed to play a crucial role in certain human pathologies, including cancer. |
| Databáze: | Directory of Open Access Journals |
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