Hyperprolactinemia and insulin resistance in drug naive patients with early onset first episode psychosis

Autor: Maria Giuseppina Petruzzelli, Mariella Margari, Antonia Peschechera, Concetta de Giambattista, Andrea De Giacomo, Emilia Matera, Francesco Margari
Jazyk: angličtina
Rok vydání: 2018
Předmět:
Zdroj: BMC Psychiatry, Vol 18, Iss 1, Pp 1-7 (2018)
Druh dokumentu: article
ISSN: 1471-244X
DOI: 10.1186/s12888-018-1827-3
Popis: Abstract Background Hyperprolactinemia and glucose and lipid metabolism abnormalities are often found in patients with schizophrenia and are generally considered secondary to the use of antipsychotic drugs. More recent studies have shown these same neuroendocrine and metabolic abnormalities in antipsychotic naïve patients with first episode psychosis (FEP), rising the hypothesis that schizophrenia itself may be related to an abnormal regulation of prolactin secretion and to impaired glucose tolerance. The aim of this study was to compare prolactin levels, glycometabolism parameters and lipid profile between a sample of 31 drug-naive adolescents in the acute phase of FEP and a control group of 23 subjects at clinical high risk (CHR) of developing psychosis. Methods The assessment involved anthropometric data (weight, height, BMI index, pubertal stage) and blood tests (levels of glucose, glycated hemoglobin, serum insulin, triglycerides, total and fractionated cholesterol, prolactin). Insulin resistance (IR) was calculated through the homeostatic model of assessment (HOMA-IR), assuming a cut-off point of 3.16 for adolescent population. FEP patients and CHR controls were compared by using Student’s t-distribution (t-test) for parametric data. P
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