Human epididymis protein 4: a novel predictor of ischemic cardiomyopathy

Autor: Yi Tang, Yinzhen Wang, Xiaoping Xu, Laura Yan Tu, Pei Huang, Xiaoyan Yang, Lihua Li, Juan Wu, Yan Zhang, Qinghua Fu, Yingli Yu, Zhaofen Zheng, Lixia Song, Yi Zhang
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: BMC Cardiovascular Disorders, Vol 21, Iss 1, Pp 1-6 (2021)
Druh dokumentu: article
ISSN: 1471-2261
DOI: 10.1186/s12872-021-02319-5
Popis: Abstract Background The prognostic value of human epididymis protein 4 (HE4) in patients with ischemic cardiomyopathy (ICM) is unknown. Methods A total of 103 patients with ICM were prospectively enrolled in this study from Hunan Provincial People’s Hospital between February 2019 and June 2019. All patients were tested for HE4 levels at baseline and follow-up. Endpoints of the study included cardiovascular death and heart failure-related hospitalization. Results A total of 96 patients with ICM were included for analysis. After a mean follow-up period of 263 (153–313) days, cardiovascular events were observed in 45 patients. Serum HE4 levels in patients with events were significantly higher than those in patients without events [188.70 (113.35–326.82) pmol/L versus 92.90 (61.50–123.20) pmol/L, P 100.2 pmol/L was higher than that in patients with HE4 ≤ 100.2 pmol/L [HR: 3.372, 95% CI: 1.409–8.065, P
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