| Autor: |
Murat Shagidulin, Nina Onishchenko, Anastasiia Grechina, Alla Nikolskaya, Mikhail Krasheninnikov, Aleksey Lyundup, Elena Volkova, Natalia Mogeiko, Artem Venediktov, Gennadii Piavchenko, Lubov Davydova, Alla Ramonova, Vladimir Bogush, Sergey Gautier |
| Jazyk: |
angličtina |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
Polymers, Vol 14, Iss 15, p 3179 (2022) |
| Druh dokumentu: |
article |
| ISSN: |
2073-4360 |
| DOI: |
10.3390/polym14153179 |
| Popis: |
Aim: In this study, we seek to check if recombinant spidroin rS1/9 is applicable for cell-engineering construct development. Novel technologies of cell and tissue engineering are relevant for chronic liver failure management. Liver regeneration may represent one of the possible treatment options if a cell-engineered construct (CEC) is used. Nowadays, one can see the continuous study of various matrices to create an appropriate CEC. Materials and Methods: We have adhered allogenic liver cells and multipotent mesenchymal bone marrow stem cells (MMSC BM) to a microgel with recombinant spidroin rS1/9. Then we have studied the developed implantable CEC in a rat model (n = 80) of chronic liver failure achieved by prolonged poisoning with carbon tetrachloride. Results: Our results demonstrate that the CECs change the values of biochemical tests and morphological parameters in chronic liver failure in rats. Conclusion: We consider there to be a positive effect from the microgel-based CECs with recombinant spidroin rS1/9 in the treatment of chronic liver failure. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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