Immunoassay for the purpose of solving current issues associated with standardization of allergen preparations
| Autor: | L. V. Nevskaya, S. F. Radunskaya, E. I. Lavrenchik, A. A. Movsesyants, V. K. Kapitanova, M. Yu. Korotkova |
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| Jazyk: | ruština |
| Rok vydání: | 2018 |
| Předmět: |
препараты аллергенов
иммуноанализ методы оценки активности препаратов аллергенов стандартизация аллергенная активность единицы аллергенной активности allergen preparations immunoassay methods for assessing the activity of allergen preparations standardization allergenic activity allergenic activity units Biotechnology TP248.13-248.65 Medicine |
| Zdroj: | Биопрепараты: Профилактика, диагностика, лечение, Vol 0, Iss 3, Pp 17-20 (2018) |
| Druh dokumentu: | article |
| ISSN: | 2221-996X 2619-1156 |
| Popis: | The present article describes principal problematic issues that refer to the standardization of allergen preparations. It is shown that at present domestic allergen preparations are being standardized by protein content in allergenic material, however, the mentioned characteristic does not reflect true allergic activity of a drug. There is a need in harmonization of domestic standardization technology for allergen preparations with the approaches of EMA (European Medicines Agency) and FDA (Food and Drug Administration), regulating their standardization in allergenic activity units, as well as the use of modern immunoassay methods for quantitative evaluation such as radioallergosorbent test, chemiluminescence analysis, immunoallergological test, enzyme-linked immunosorbent assay with inhibition phase etc. |
| Databáze: | Directory of Open Access Journals |
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