Interrogation of the microenvironmental landscape in spinal ependymomas reveals dual functions of tumor-associated macrophages

Autor: Qianqian Zhang, Sijin Cheng, Yongzhi Wang, Mengdi Wang, Yufeng Lu, Zengqi Wen, Yuxin Ge, Qiang Ma, Youqiao Chen, Yaowu Zhang, Ren Cao, Min Li, Weihao Liu, Bo Wang, Qian Wu, Wenqing Jia, Xiaoqun Wang
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Druh dokumentu: article
ISSN: 2041-1723
DOI: 10.1038/s41467-021-27018-9
Popis: The intratumoural heterogeneity of spinal ependymomas and the role of microglia in tumour progression remain underexplored. Here, the authors perform single-cell RNA- and ATAC-sequencing data analysis of three subtypes and reveal tumour-associated macrophage subsets with distinct functional phenotypes.
Databáze: Directory of Open Access Journals