Fuzapladib in a randomized controlled multicenter masked study in dogs with presumptive acute onset pancreatitis

Autor: Joerg M. Steiner, Chantal Lainesse, Yuya Noshiro, Yumiko Domen, Heather Sedlacek, Stephen E. Bienhoff, Kelly P. Doucette, David L. Bledsoe, Hiroshi Shikama
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: Journal of Veterinary Internal Medicine, Vol 37, Iss 6, Pp 2084-2092 (2023)
Druh dokumentu: article
ISSN: 1939-1676
0891-6640
DOI: 10.1111/jvim.16897
Popis: Abstract Background Currently, no specific treatment is available for acute onset pancreatitis (AP), and management relies on symptomatic and supportive standard of care (SOC). Fuzapladib is a novel leukocyte function‐associated antigen type‐1 (LFA‐1) activation inhibitor, blocking activation and subsequent adhesion and migration of neutrophils, potentially decreasing the risk of pancreatitis progression and systemic inflammation. Objective Evaluate the safety and clinical response of dogs with AP after 3 days of administration of fuzapladib. Animals Sixty‐one client‐owned dogs with presumptive AP. Methods Randomized, masked, and placebo controlled multicenter study. Sixty‐one dogs with AP were included for safety assessment, whereas 35 evaluable cases (fuzapladib, n = 16; placebo, n = 19) were included for clinical evaluation. Clinical improvement was assessed based on the change in the modified clinical activity index (MCAI) score on Day 3 compared to Day 0. Secondary variables included canine acute pancreatitis clinical severity index (CAPCSI) scores and serum concentrations of canine pancreatic lipase immunoreactivity, cytokines, and C‐reactive protein. Results Fuzapladib was well tolerated by all treated dogs. Mean change in MCAI scores was significantly higher in the fuzapladib‐treated (−7.75) than the placebo group (−5.68; P = .02, 95% confidence interval [CI] for the difference, −4.33, −0.35), suggesting clinical improvement in fuzapladib‐treated dogs. No significant difference was found in any of the secondary variables between groups. Conclusions and Clinical Relevance Administration of fuzapladib to dogs was safe, and a favorable response was detected in 2 clinical activity scores. Effects of fuzapladib on survival and duration of hospitalization were not studied.
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