| Autor: |
Hyun Young Kim, Sadatsugu Sakane, Alvaro Eguileor, Raquel Carvalho Gontijo Weber, Wonseok Lee, Xiao Liu, Kevin Lam, Kei Ishizuka, Sara Brin Rosenthal, Karin Diggle, David A. Brenner, Tatiana Kisseleva |
| Jazyk: |
angličtina |
| Rok vydání: |
2024 |
| Předmět: |
|
| Zdroj: |
Cellular and Molecular Gastroenterology and Hepatology, Vol 17, Iss 1, Pp 93-106 (2024) |
| Druh dokumentu: |
article |
| ISSN: |
2352-345X |
| DOI: |
10.1016/j.jcmgh.2023.09.008 |
| Popis: |
Liver fibrosis of different etiologies is a serious health problem worldwide. There is no effective therapy available for liver fibrosis except the removal of the underlying cause of injury or liver transplantation. Development of liver fibrosis is caused by fibrogenic myofibroblasts that are not present in the normal liver, but rather activate from liver resident mesenchymal cells in response to chronic toxic or cholestatic injury. Many studies indicate that liver fibrosis is reversible when the causative agent is removed. Regression of liver fibrosis is associated with the disappearance of activated myofibroblasts and resorption of the fibrous scar. In this review, we discuss the results of genetic tracing and cell fate mapping of hepatic stellate cells and portal fibroblasts, their specific characteristics, and potential phenotypes. We summarize research progress in the understanding of the molecular mechanisms underlying the development and reversibility of liver fibrosis, including activation, apoptosis, and inactivation of myofibroblasts. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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