| Autor: |
Suming Wang, Victor Zota, Melanie Y. Vincent, Donna Clossey, Jian Jenny Chen, Michael Cieslewicz, Randolph S. Watnick, James Mahoney, Jing Watnick |
| Jazyk: |
angličtina |
| Rok vydání: |
2024 |
| Předmět: |
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| Zdroj: |
npj Precision Oncology, Vol 8, Iss 1, Pp 1-10 (2024) |
| Druh dokumentu: |
article |
| ISSN: |
2397-768X |
| DOI: |
10.1038/s41698-024-00774-9 |
| Popis: |
Abstract Despite the development of cancer biomarkers and targeted therapies, most cancer patients do not have a specific biomarker directly associated with effective treatment options. We have developed VT1021 that induces the expression of thrombospondin-1 (TSP-1) in myeloid-derived suppressor cells (MDSCs) recruited to the tumor microenvironment (TME). Our studies identified CD36 and CD47 as dual biomarkers that can be used as patient stratifying tools and prognostic biomarkers for VT1021 treatment. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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