REACTIVITY OF BLOOD LYMPHOCYTES IN PULMONARY TUBERCULOSIS
| Autor: | R. R. Khasanova, O. V. Voronkova, O. I. Urazova, V. V. Novitsky, A. K. Strelis, Yu. V. Stambula, A. E. Kolosova, V. A. Serebryakova, I. O. Naslednikova, O. V. Kolokolova, T. E. Budkina, N. P. Pirogova |
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| Jazyk: | ruština |
| Rok vydání: | 2014 |
| Předmět: | |
| Zdroj: | Медицинская иммунология, Vol 11, Iss 1, Pp 35-40 (2014) |
| Druh dokumentu: | article |
| ISSN: | 1563-0625 2313-741X |
| DOI: | 10.15789/1563-0625-2009-1-35-40 |
| Popis: | Evaluation of proliferative and IL-2-producing activity of peripheral blood lymphocytes wasperformed, using cultural methods, in patients with drug-sensitive and drug-resistant infiltrative pulmonary tuberculosis. The cell testing was performed at basal level and following in vitro stimulation with recombinant IL-2 and M. tuberculosis antigens. It was established that clinical course of infiltrative pulmonary tuberculosis, independently on drug sensitivity/resistance of the infectious pathogen, is accompanied by suppression of spontaneous lymphoproliferation. The levels of induced IL-2 production in drug-sensitive tuberculosis proved to be increased, whereas a reserve of IL-2-secreting reactivity of blood lymphocytes was lower than in drugresistant infection. Also, it was revealed that the level of lymphoproliferative response induced by IL-2, does not depend on clinical variant of tuberculosis, whereas stimulation of IL-2 production in blood lymphocytes is attained only in cases of drug-resistant tuberculosis variant. |
| Databáze: | Directory of Open Access Journals |
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