Characterization of cytomegalovirus disease in solid organ transplant recipients by markers of inflammation in plasma.

Autor: Halvor Rollag, Thor Ueland, Anders Asberg, Anders Hartmann, Alan G Jardine, Atul Humar, Mark D Pescovitz, Angelo A Bignamini, Pål Aukrust
Jazyk: angličtina
Rok vydání: 2013
Předmět:
Zdroj: PLoS ONE, Vol 8, Iss 4, p e60767 (2013)
Druh dokumentu: article
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0060767
Popis: While several studies have examined the general inflammatory responses in relation to cytomegalovirus infection, the identification of the various inflammatory mediators as well as their relative importance is far from clear.Solid organ recipients enrolled in an international multicenter trial of cytomegalovirus disease treatment (the VICTOR study) were analyzed (n = 289) (ClinicalTrials.gov NCT00431353). Plasma markers of inflammation and endothelial cell activation were assessed at baseline by enzyme immunoassays.The major findings were: (i) Plasma levels of the CXC-chemokine interferon-inducible protein-10 (P
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