Significance of predicted future liver remnant volume on liver failure risk after major hepatectomy: a case matched comparative study

Autor: R. Piccus, K. Joshi, J. Hodson, D. Bartlett, N. Chatzizacharias, B. Dasari, J. Isaac, R. Marudanayagam, D. F. Mirza, J. K. Roberts, R. P. Sutcliffe
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: Frontiers in Surgery, Vol 10 (2023)
Druh dokumentu: article
ISSN: 2296-875X
DOI: 10.3389/fsurg.2023.1174024
Popis: IntroductionFuture liver remnant volume (FLRV), a risk factor for liver failure (PHLF) after major hepatectomy (MH), is not routinely measured. This study aimed to evaluate the association between FLRV and PHLF.Patients and methodsAll patients undergoing MH (4 + segments) between 2011 and 2018 were identified from a prospectively maintained single-centre database. Perioperative data were collected for patients with PHLF, who were matched (1:2) with non-PHLF controls. FLRV and FLRV% (i.e., % of total liver volume) were calculated retrospectively from preoperative CT scans using Synapse-3D software, and compared between the PHLF and matched control groups.ResultsOf 711 patients undergoing MH, PHLF occurred in 27 (3.8%), of whom 24 had preoperative CT scans available. These patients were matched to 48 non-PHLF controls, 98% of whom were classified as being at high risk of PHLF on preoperative risk scoring. FLRV% was significantly lower in the PHLF group, compared to matched controls (median: 28.7 vs. 35.2%, p = 0.010), with FLRV%
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