Using the power of innate immunoprofiling to understand vaccine design, infection, and immunity
| Autor: | Jennifer Connors, Gina Cusimano, Nathan Mege, Kyra Woloszczuk, Emily Konopka, Matthew Bell, David Joyner, Jennifer Marcy, Virginie Tardif, Michele A. Kutzler, Roshell Muir, Elias K. Haddad |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2023 |
| Předmět: |
systems immunology
innate immune profiling innate immune cells bioinformatics rna sequencing o-link gwas metabolomics multiplex cytokine profiling luminex mesoscale multi-color flow cytometry phospho-flow cytof mibi vaccinology infectious disease Immunologic diseases. Allergy RC581-607 Therapeutics. Pharmacology RM1-950 |
| Zdroj: | Human Vaccines & Immunotherapeutics, Vol 19, Iss 3 (2023) |
| Druh dokumentu: | article |
| ISSN: | 2164-5515 2164-554X 21645515 |
| DOI: | 10.1080/21645515.2023.2267295 |
| Popis: | In the field of immunology, a systems biology approach is crucial to understanding the immune response to infection and vaccination considering the complex interplay between genetic, epigenetic, and environmental factors. Significant progress has been made in understanding the innate immune response, including cell players and critical signaling pathways, but many questions remain unanswered, including how the innate immune response dictates host/pathogen responses and responses to vaccines. To complicate things further, it is becoming increasingly clear that the innate immune response is not a linear pathway but is formed from complex networks and interactions. To further our understanding of the crosstalk and complexities, systems-level analyses and expanded experimental technologies are now needed. In this review, we discuss the most recent immunoprofiling techniques and discuss systems approaches to studying the global innate immune landscape which will inform on the development of personalized medicine and innovative vaccine strategies. |
| Databáze: | Directory of Open Access Journals |
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