Developmental thyroid disruption causes long-term impacts on immune cell function and transcriptional responses to pathogen in a small fish model

Autor:	Leah M. Thornton Hampton, Miranda G. Finch, Christopher J. Martyniuk, Barney J. Venables, Marlo K. Sellin Jeffries
Jazyk:	angličtina
Rok vydání:	2021
Předmět:	Medicine Science
Zdroj:	Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Druh dokumentu:	article
ISSN:	2045-2322
DOI:	10.1038/s41598-021-93929-8
Popis:	Abstract Current evidence suggests thyroid hormones (THs) impact development of the immune system, but few studies have explored the connection between the thyroid and immune systems, especially in fish. This is important as some environmental contaminants disrupt TH homeostasis and may thus have negative impacts on the immune system. To determine the long-term consequences of early life stage (ELS) hypothyroidism on immune function, fathead minnows were exposed to the model thyroid hormone suppressant propylthiouracil (PTU) from
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/d0f4b5517445442aafa06bb922bf84be Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF Plný text ve formátu HTML
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