| Autor: |
Chaoyang Gong, Xi Yang, Shui-Jing Tang, Qian-Qian Zhang, Yanqiong Wang, Yi-Ling Liu, Yu-Cheng Chen, Gang-Ding Peng, Xudong Fan, Yun-Feng Xiao, Yun-Jiang Rao, Yuan Gong |
| Jazyk: |
angličtina |
| Rok vydání: |
2023 |
| Předmět: |
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| Zdroj: |
Light: Science & Applications, Vol 12, Iss 1, Pp 1-10 (2023) |
| Druh dokumentu: |
article |
| ISSN: |
2047-7538 |
| DOI: |
10.1038/s41377-023-01335-8 |
| Popis: |
Abstract Biomarker detection is key to identifying health risks. However, designing sensitive and single-use biosensors for early diagnosis remains a major challenge. Here, we report submonolayer lasers on optical fibers as ultrasensitive and disposable biosensors. Telecom optical fibers serve as distributed optical microcavities with high Q-factor, great repeatability, and ultralow cost, which enables whispering-gallery laser emission to detect biomarkers. It is found that the sensing performance strongly depends on the number of gain molecules. The submonolayer lasers obtained a six-order-of-magnitude improvement in the lower limit of detection (LOD) when compared to saturated monolayer lasers. We further achieve an ultrasensitive immunoassay for a Parkinson’s disease biomarker, alpha-synuclein (α-syn), with a lower LOD of 0.32 pM in serum, which is three orders of magnitude lower than the α-syn concentration in the serum of Parkinson’s disease patients. Our demonstration of submonolayer biolaser offers great potentials in high-throughput clinical diagnosis with ultimate sensitivity. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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