The Use of CytoSorb Therapy in Critically Ill COVID-19 Patients: Review of the Rationale and Current Clinical Experiences

Autor: Juan Carlos Ruiz-Rodríguez, Zsolt Molnar, Efthymios N. Deliargyris, Ricard Ferrer
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: Critical Care Research and Practice, Vol 2021 (2021)
Druh dokumentu: article
ISSN: 2090-1305
2090-1313
DOI: 10.1155/2021/7769516
Popis: The COVID-19 pandemic has led to the biggest global health crisis of our lifetime. There is accumulating evidence that a substantial number of critically ill COVID-19 patients exhibit a dysregulated host response manifesting as cytokine storm or cytokine release syndrome, which in turn contributes to the high observed rates of mortality. Just as in other hyperinflammatory conditions, extracorporeal cytokine removal may have potential beneficial effects in this subgroup of COVID-19 patients. The CytoSorb blood purification device is the most extensively investigated cytokine removal platform with considerable evidence suggesting that early intervention can provide rapid hemodynamic stabilization and improvement in vital organ functions. The purpose of this review is to provide an overview of the pathophysiological background of hyperinflammation in COVID-19 and to summarize the currently available evidence on the effects of hemoadsorption in these patients.
Databáze: Directory of Open Access Journals
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