| Autor: |
Sachini Ranasinghe, Ankur Jain, Yasmeen Taha, Eileen Handberg, B. Delia Johnson, Vera Bittner, George Sopko, Carl J. Pepine, R. David Anderson, C. Noel Bairey Merz |
| Jazyk: |
angličtina |
| Rok vydání: |
2024 |
| Předmět: |
|
| Zdroj: |
American Heart Journal Plus, Vol 43, Iss , Pp 100411- (2024) |
| Druh dokumentu: |
article |
| ISSN: |
2666-6022 |
| DOI: |
10.1016/j.ahjo.2024.100411 |
| Popis: |
Background: Women have smaller coronary size than men independent of body surface area. Female to male heart transplantation demonstrates coronary lumen enlargement. Purpose: To investigate relationships between endogenous androgens and coronary luminal size in women with suspected ischemic heart disease (IHD). Methods: We analyzed 69 women with available androgen levels. Results: Group mean age was 54 ± 10 years with 64 % post-menopausal. Lumen cross-sectional area (CSA) and external elastic membrane (EEM) CSA positively correlated with free testosterone (FT) (r = 0.29, p = 0.049; r = 0.29, p = 0.01), respectively, and negatively correlated with SHBG (r = −0.26, p = 0.03; r = −0.29, p = 0.02), respectively. Atheroma CSA positively correlated with FT (r = 0.24. p = 0.05). These correlations became non-significant after adjusting for waist circumference. Conclusions: In women with suspected ischemic heart disease, endogenous androgens, coronary atheroma and luminal size are related, and may be moderated by waist circumference. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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